Effect of Electrode Arrangement on Transdermal Glucose Extraction and Detection by Reverse Iontophoresis

This work investigated the effect of electrode arrangement on transdermal glucose extraction and detection by reverse iontophoresis (RI) through simulation and in-vitro experiments. According to the results, more adjacent distance between the two extraction electrodes makes larger flux of glucose, however, the extraction will affect the performance of glucose sensor. Therefore, we then change the position of the glucose sensor to investigate the effect further. Finally, we obtained an optimized electrode arrangement to get a big glucose extraction flux while has little harm to the glucose sensor's sensitivity. This work provides insights into the design of electrode arrangement of the RI-based detection devices.