Physical Mechanism of Non-Invasive Skin Penetration Enhancement Method Based on Thermal Permeability Effect

Thermal is a well-established and promising non-invasive method for improving skin permeability, which can reduce the skin barrier and enable efficient transdermal diagnosis and treatment [1]. However, the underlying mechanism of thermal permeability enhancement remains unclear. To address this gap, this paper investigates the relationship between thermal permeability enhancement and the physical properties of the skin. Through modeling, simulations, and experiments, the mechanism of skin thermal permeability enhancement is explored from three key perspectives: skin longitudinal impedance, hair follicle pore size, and the interstitial fluid extraction rate. Explore the relationship between epidermal temperature and skin permeability, and provide theoretical support for transdermal diagnosis and treatment based on skin thermal permeation effect. This paper aims to investigate the mechanism of action of skin thermal permeability effect. The research objectives are to explore the relationship between skin permeability and skin physicochemical properties, establish the relationship between epidermal temperature and interstitial fluid extraction rate, provide theoretical support for transdermal interstitial fluid extraction based on skin thermal permeability effect, and lay a foundation for the diagnostic application of transdermal interstitial fluid extraction through reverse iontophoresis to monitor physiological parameters. The experimental results show that the skin permeability changes with temperature in a certain pattern.