A Biodegradable, Wireless, Implantable Micropump for Peripheral Nerve Repair

Peripheral Nerve Injury (PNI) leads to significant motor and sensory impairments, with limited recovery potential in injuries exceeding 3 cm, Conventional treatments often fail to achieve full functional restoration. Suction-based approaches at lesion sites have demonstrated promising outcomes in nerve regeneration. This work presents a novel wireless, magnetically actuated micropump composed of biodegradable materials, such as poly(octamethylene-maleate(anhydride)citrate) (POMaC), for nerve repair applications. The micropump integrates a magnetic ring within its membrane, enabling deflection under alternating magnetic field <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$(4\ \text{Hz},\ \pm 150\ \text{mT})$</tex>, generating a net under-pressure of 1.3 kPa within 8 minutes. It provides a potential solution to facilitate nerve healing.