Optimal time and volume of fluid resuscitation in patients with sepsis: a nationwide multicenter cohort study

The optimal fluid resuscitation strategy for managing sepsis remains unknown. We aimed to examine the independent and joint associations of infusion time and volume of fluid resuscitation on mortality in patients with sepsis. We analyzed adult patients with sepsis who received > 20 mL/kg of fluid for initial resuscitation within 6 h after the start of fluid resuscitation from prospectively collected nationwide data at 15 hospitals in South Korea between September 2019 and December 2022.The volume of administered fluid (mL/kg) was categorized into six groups (20 to < 25, 25 to < 30, 30 to < 35, 35 to < 40, 40 to < 45, and ≥ 45) and infusion time (h) was categorized into two groups (≤ 3 and > 3). Among a total of 1305 patients, a fluid volume of 40 to < 45 mL/kg with an infusion time of ≤ 3 h was significantly associated with a lower 28-day mortality rate compared with that in 20 to < 25 mL/kg (hazard ratio [HR], 0.18; 95% confidence interval [CI], 0.04-0.87). This nationwide cohort study of patients with sepsis showed that administering a higher (> 30%) volume of fluid than the current recommendation within 3 h was associated with a lower risk of mortality.

Authors

Institutions

Publication Details

Journal
Scientific Reports
Published
2025-08-19
DOI
https://doi.org/10.1038/s41598-025-14854-8
Citations
1
Primary Topic
Sepsis Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
1.35

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Optimal time and volume of fluid resuscitation in patients with sepsis: a nationwide multicenter cohort study

Jeongwon Heo, Gil Myeong Seong, Kyeongman Jeon, Jae Young Moon et al.
1 citations
Scientific Reports
Sepsis Diagnosis and Treatment
1.35
article

Optimal time and volume of fluid resuscitation in patients with sepsis: a nationwide multicenter cohort study

Jeongwon Heo, Gil Myeong Seong, Kyeongman Jeon, Jae Young Moon, Suk‐Kyung Hong, Younsuck Koh, Song-I. Lee, Mi Hyeon Park, Heung Bum Lee, Tai Sun Park, Su Hwan Lee, Jin Won Huh, Young‐Jae Cho, Hyung Koo Kang, Jee Hwan Ahn, Ryoung‐Eun Ko, Dong‐gon Hyun, Kyung Chan Kim, Youjin Chang, Sung Yoon Lim, Gee Young Suh, Jae Myeong Lee, Woo Hyun Cho, Sang‐Bum Hong, Sang‐Min Lee, Sunghoon Park, Yeon Joo Lee, Eun Young Choi, Su Yeon Lee, Sang Hyun Kwak, Jong-Joon Ahn, Dong Kyu Oh, Chae-Man Lim
article en
1 citations

Abstract

The optimal fluid resuscitation strategy for managing sepsis remains unknown. We aimed to examine the independent and joint associations of infusion time and volume of fluid resuscitation on mortality in patients with sepsis. We analyzed adult patients with sepsis who received > 20 mL/kg of fluid for initial resuscitation within 6 h after the start of fluid resuscitation from prospectively collected nationwide data at 15 hospitals in South Korea between September 2019 and December 2022.The volume of administered fluid (mL/kg) was categorized into six groups (20 to < 25, 25 to < 30, 30 to < 35, 35 to < 40, 40 to < 45, and ≥ 45) and infusion time (h) was categorized into two groups (≤ 3 and > 3). Among a total of 1305 patients, a fluid volume of 40 to < 45 mL/kg with an infusion time of ≤ 3 h was significantly associated with a lower 28-day mortality rate compared with that in 20 to < 25 mL/kg (hazard ratio [HR], 0.18; 95% confidence interval [CI], 0.04-0.87). This nationwide cohort study of patients with sepsis showed that administering a higher (> 30%) volume of fluid than the current recommendation within 3 h was associated with a lower risk of mortality.

Scientific ReportsVol. 15(1)
Ulsan College (KR), Asan Medical Center (KR), University of Ulsan (KR)
Seoul National University Bundang Hospital, Korea Disease Control and Prevention Agency, Hanyang University, Catholic University of Daegu, Jeju National University, Chonnam National University, Chungnam National University, Kangwon National University, Pusan National University, Seoul National University, Hallym University, Inje University, Korea University, Yeungnam University, Seoul National University Hospital, Chungnam National University Hospital, Jeju National University Hospital, Jeonbuk National University, Korea University Anam Hospital, Samsung, Korea Centers for Disease Control and Prevention, Ulsan University Hospital
Good health and well-being
Openalex Percentile: Top 16%
Sepsis Diagnosis and Treatment
1.35
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.