Association of Lower Alanine Transaminase (ALT) and Aspartate Aminotransferase (AST) Levels With Eyelid Edema in Graves' Orbitopathy: A Retrospective Cross-Sectional Study
This study demonstrated an association between liver enzymes (AST and ALT) and eyelid edema in GO patients. The findings suggest a potential link between liver function and the pathogenesis of GO-related edema. Further prospective studies are required to clarify the causal relationship, explore the underlying mechanisms, and assess the clinical utility of liver enzymes as biomarkers for GO severity or progression.
Authors
- Yuying Xiang (ORCID: https://orcid.org/0000-0001-8991-7066)
- Shuang Wang (ORCID: https://orcid.org/0000-0003-3571-8840)
- Rui Li (ORCID: https://orcid.org/0000-0002-4682-9944)
- Guang Zhao (ORCID: https://orcid.org/0000-0002-7389-1831)
- Junjie Yang (ORCID: https://orcid.org/0000-0002-4335-9705)
- Fagang Jiang
Institutions
- Wuhan Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Cureus
- Published
- 2025-08-19
- DOI
- https://doi.org/10.7759/cureus.90519
- Citations
- 1
- Primary Topic
- Ophthalmology and Eye Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Moonshot Research and Development Program