Mitochondrial bioenergetics and intracellular calcium concentration in primary myotubes from mouse models of malignant hyperthermia
The high-throughput method used produced data consistent with findings in skeletal muscle fibres, but with a greater sensitivity to genotypic effects. This validates the use of cultured myotubes in lieu of muscle fibres in studying mitochondrial bioenergetics in models of MH, and indicates that mitochondrial bioenergetics are not directly affected by myoplasmic calcium concentrations in young MH mice.
Authors
- Leon Chang (ORCID: https://orcid.org/0009-0003-5223-7616)
- Philip M. Hopkins (ORCID: https://orcid.org/0000-0002-8127-1739)
- Vikas Kaura (ORCID: https://orcid.org/0000-0002-8984-9662)
- Marie‐Anne Shaw (ORCID: https://orcid.org/0000-0001-6718-5423)
Institutions
- University of Leeds (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- St James's University Hospital (GB)
Publication Details
- Journal
- British Journal of Anaesthesia
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1016/j.bja.2025.05.060
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- British Journal of Anaesthesia
- National Institute for Health and Care Research
- Royal College of Anaesthetists