Association of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging

Higher WMHVR was associated with HAR between approximately 70 and 73 years, independent of CVRF levels, <i>APOE</i>-ε4 status, and Aβ load, and not mediated by markers of neuroaxonal degradation. Although AD-specific pathology is typically considered the main cause of accelerated HAR, we demonstrated that HAR is also linked to deteriorating WM health. These results will need to be replicated in more diverse cohorts with longer follow-up periods to confirm the findings.

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Publication Details

Journal
Neurology
Published
2025-08-19
DOI
https://doi.org/10.1212/wnl.0000000000213975
Citations
1
Primary Topic
Neurological Disease Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
0.84
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article

Association of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging

Josephine Barnes, Heidi Murray‐Smith, Jennifer M. Nicholas, Ashvini Keshavan et al.
1 citations
Neurology
Neurological Disease Mechanisms and Treatments
0.84
article

Association of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging

Josephine Barnes, Heidi Murray‐Smith, Jennifer M. Nicholas, Ashvini Keshavan, David M. Cash, Carole H. Sudre, Jonathan M. Schott, Thomas H. Brown, Marcus Richards, William Coath, Sarah‐Naomi James, Frederik Barkhof, Ian B. Malone, Sarah E Keuss
article en
1 citations

Abstract

Higher WMHVR was associated with HAR between approximately 70 and 73 years, independent of CVRF levels, <i>APOE</i>-ε4 status, and Aβ load, and not mediated by markers of neuroaxonal degradation. Although AD-specific pathology is typically considered the main cause of accelerated HAR, we demonstrated that HAR is also linked to deteriorating WM health. These results will need to be replicated in more diverse cohorts with longer follow-up periods to confirm the findings.

NeurologyVol. 105(5)
Hawler Medical University (IQ), King's College London (GB), London School of Hygiene & Tropical Medicine (GB), UK Dementia Research Institute (GB), MRC Unit for Lifelong Health and Ageing (GB), National Hospital for Neurology and Neurosurgery (GB), University College London (GB), Vrije Universiteit Amsterdam (NL)
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Openalex Percentile: Top 23%
Neurological Disease Mechanisms and Treatments
0.84
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Association of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging — Josephine Barnes, Heidi Murray‐Smith, et al. · Neurology (2025) | TGRS Research Map | TGRS