Integrating MRI Volume and Plasma p-Tau217 for Amyloid Risk Stratification in Early-Stage Alzheimer Disease
The 2-stage diagnostic workflow integrating MRI-based risk stratification and plasma p-tau217 testing accurately identified individuals with Aβ PET positivity in early-stage AD, substantially reducing the need for additional biomarker testing. However, the generalizability may be limited by modest incremental improvement over baseline models and limited racial and ethnic diversity.
Authors
- Jun Pyo Kim (ORCID: https://orcid.org/0000-0003-4376-3107)
- Min Young Chun (ORCID: https://orcid.org/0000-0003-3731-6132)
- Nicholas James Ashton (ORCID: https://orcid.org/0000-0002-3579-8804)
- Duk Lyul Na (ORCID: https://orcid.org/0000-0002-0098-7592)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Fernando González‐Ortiz (ORCID: https://orcid.org/0000-0001-7897-9456)
- Kichang Kwak (ORCID: https://orcid.org/0000-0003-4542-0001)
- Seongbeom Park (ORCID: https://orcid.org/0000-0002-0759-6826)
- Hyemin Jang (ORCID: https://orcid.org/0000-0003-3152-1274)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Sang Won Seo (ORCID: https://orcid.org/0000-0002-8747-0122)
- Jihwan Yun (ORCID: https://orcid.org/0000-0002-2436-4947)
- Sung Hoon Kang (ORCID: https://orcid.org/0000-0002-2481-0302)
- Hyunjin Jo (ORCID: https://orcid.org/0000-0001-9563-1849)
- Hee Jin Kim (ORCID: https://orcid.org/0000-0002-3186-9441)
- Eun‐Joo Kim (ORCID: https://orcid.org/0000-0002-8460-1377)
- Daeun Shin (ORCID: https://orcid.org/0000-0003-4834-1026)
- Michael Walter Weiner (ORCID: https://orcid.org/0000-0002-0144-1954)
- Kok Hing Lim (ORCID: https://orcid.org/0000-0003-0653-2342)
- Heoung‐Keun Kang (ORCID: https://orcid.org/0009-0009-5896-4615)
- S.F. Yim (ORCID: https://orcid.org/0000-0002-9357-768X)
Institutions
- University of Science and Technology of China (CN)
- University of Wisconsin–Madison (US)
- University of California, San Francisco (US)
- King's College London (GB)
- Neurosciences Institute (US)
- Yonsei University (KR)
- South London and Maudsley NHS Foundation Trust (GB)
- Hong Kong University of Science and Technology (HK)
- Korea University Medical Center (KR)
- Stavanger University Hospital (NO)
- Sahlgrenska University Hospital (SE)
- Samsung Medical Center (KR)
- Seoul National University Hospital (KR)
- Kyung Hee University (KR)
- Sorbonne Université (FR)
- Pusan National University Hospital (KR)
- Syneos Health (South Korea) (KR)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- Institut du Cerveau (FR)
- Yonsei University Health System (KR)
- University College London (GB)
- Sungkyunkwan University (KR)
- University of Gothenburg (SE)
Publication Details
- Journal
- Neurology
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1212/wnl.0000000000213954
- Citations
- 3
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Alzheimer's Drug Discovery Foundation
- Familjen Erling-Perssons Stiftelse
- Stiftelsen för Gamla Tjänarinnor
- National Institute for Health and Care Research
- University College London
- European Commission
- National Research Foundation
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Hjärnfonden
- Vetenskapsrådet
- Ministry of Science and ICT, South Korea
- UK Dementia Research Institute
- Samsung
- Korea National Institute of Health
- Institute for Information and Communications Technology Promotion