Immunogenicity and safety of a rabies-based highly pathogenic influenza A virus H5 vaccine in cattle
The circulation of highly pathogenic H5 influenza A viruses in cattle, other mammals, and wildlife threatens animal and human health. To address this, we vaccinated heifer-calves with a deactivated rabies-virus-based H5 vaccine, which was well-tolerated and elicited neutralizing antibodies against both clade-1 and clade-2.3.4.4b H5N1 viruses, comparable to naturally H5-infected and convalescing cows. The immune responses to the vaccine platform were durable for at least 200 days and unaffected by preexisting RABV immunity.
Authors
- Nir Paran (ORCID: https://orcid.org/0000-0001-5143-9660)
- Drishya Kurup (ORCID: https://orcid.org/0000-0002-3959-7700)
- Kimberly H. Lohmeyer (ORCID: https://orcid.org/0000-0001-5656-8568)
- Ismaila Shittu (ORCID: https://orcid.org/0000-0002-2977-9578)
- Catherine Olal (ORCID: https://orcid.org/0009-0006-2288-2026)
- Dennis A. Bente (ORCID: https://orcid.org/0000-0002-5150-7368)
- Christoph Wirblich (ORCID: https://orcid.org/0000-0002-0584-7281)
- Matthias J. Schnell (ORCID: https://orcid.org/0000-0001-9040-9405)
- Pia U. Olafson (ORCID: https://orcid.org/0000-0002-0433-6172)
- Gregory C. Gray (ORCID: https://orcid.org/0000-0002-4628-5908)
- Stacey Schultz‐Cherry (ORCID: https://orcid.org/0000-0002-2021-727X)
- Alessandro Tarquinio
Institutions
- St. Jude Children's Research Hospital (US)
- Thomas Jefferson University (US)
- Knipling-Bushland U.S. Livestock Insects Research Laboratory (US)
- The University of Texas Medical Branch at Galveston (US)
Publication Details
- Journal
- npj Vaccines
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1038/s41541-025-01238-2
- Citations
- 3
- Primary Topic
- Rabies epidemiology and control
- Type
- article
- Field-Weighted Citation Impact
- 3.11
Funders
- Agricultural Research Service
- Sealy Institute for Vaccine Sciences, University of Texas Medical Branch
- National Cancer Institute