Squash cytology- Useful tool to diagnose fungal infection in COVID patient

Objective: This study aims to diagnose fungal infections in post-COVID-19 patients using both squash cytology and histology to minimize morbidity and mortality. Materials and Methods: Conducted at a tertiary medical center over six months, this prospective observational study included hospitalized patients who tested positive for SARS-CoV-1 (COVID-19) and exhibited clinically diagnosed or suspected fungal infections. Representative samples were analyzed using cytological squash smears and histopathology sections, stained with H&E, PAP, MGG, and PAS. Results: Among the 45 patients—34 males and 11 females—35 were diagnosed with mucormycosis through both histology and cytology. Additionally, two patients each were identified with aspergillosis and candidiasis through histology. Conclusion: For prompt diagnosis and management, leading to improved outcomes, squash cytology and histopathology prove to be more efficient and less time-consuming than culture methods.