Phase II Study of <sup>177</sup> Lu-DOTATATE for Progressive Metastatic Pheochromocytomas and Paragangliomas: Interim Analysis of Efficacy, Safety, and Biomarkers

<sup>177</sup>Lu-DOTATATE demonstrated effectiveness and acceptable safety profile for progressive, metastatic PPGL. CRS may occur but can be mitigated through pretreatment with antihypertensives, and, when appropriate, intensified monitoring in the ICU with intravenous antihypertensives.

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Publication Details

Journal
Journal of Clinical Oncology
Published
2025-08-19
DOI
https://doi.org/10.1200/jco-25-00791
Citations
4
Primary Topic
Adrenal and Paraganglionic Tumors
Type
article
Field-Weighted Citation Impact
8.03
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article

Phase II Study of 177 Lu-DOTATATE for Progressive Metastatic Pheochromocytomas and Paragangliomas: Interim Analysis of Efficacy, Safety, and Biomarkers

Sara Talvacchio, Erich P. Huang, Corina Millo, Barış Türkbey et al.
4 citations
Journal of Clinical Oncology
Adrenal and Paraganglionic Tumors
8.03
article

Phase II Study of 177 Lu-DOTATATE for Progressive Metastatic Pheochromocytomas and Paragangliomas: Interim Analysis of Efficacy, Safety, and Biomarkers

Sara Talvacchio, Erich P. Huang, Corina Millo, Barış Türkbey, Inna Shamis, Jaydira Del Rivero, Joanna Kłubo-Gwieździńska, Joanna H. Shih, Jorge A. Carrasquillo, Esther Mena, Karel Pacák, Frank I. Lin, Freddy E. Escorcia, Liza Lindenberg, Abhishek Jha, Peter Herscovitch, Clara Chen, Joy Zou, Yating Teng, Peter L. Choyke
article en
4 citations

Abstract

<sup>177</sup>Lu-DOTATATE demonstrated effectiveness and acceptable safety profile for progressive, metastatic PPGL. CRS may occur but can be mitigated through pretreatment with antihypertensives, and, when appropriate, intensified monitoring in the ICU with intravenous antihypertensives.

Journal of Clinical OncologyVol. 43(28)
National Institutes of Health (US), Uniformed Services University of the Health Sciences (US), National Institute of Diabetes and Digestive and Kidney Diseases (US), Office of the Director (US), National Cancer Institute (UA), Institute of Endocrinology (CZ), National Cancer Institute (US), Eunice Kennedy Shriver National Institute of Child Health and Human Development (US), National Institutes of Health Clinical Center (US)
Openalex Percentile: Top 2%
Adrenal and Paraganglionic Tumors
8.03
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