Germline Pathogenic/Likely Pathogenic Mutations and Subsequent Neoplasms Among Childhood Cancer Survivors: A Report From the Children's Oncology Group ALTE03N1 Study

These findings provide a risk-based approach for identifying childhood cancer survivors who could be referred for genetic testing, informing surveillance strategies on the basis of refined risk classification.

Authors

Joshua Richman (ORCID: https://orcid.org/0000-0002-6166-7488)
Liting Zhou (ORCID: https://orcid.org/0009-0005-9995-6348)
M. A. Sheikh (ORCID: https://orcid.org/0000-0002-1606-8945)
Lindsey Hageman (ORCID: https://orcid.org/0009-0009-2396-5634)
Ravi Bhatia (ORCID: https://orcid.org/0000-0001-5740-2316)
Changde Cheng (ORCID: https://orcid.org/0000-0002-2458-2522)
Noha Sharafeldin (ORCID: https://orcid.org/0000-0001-8835-8899)
Patrick J. Trainor (ORCID: https://orcid.org/0000-0002-3012-9716)
Danielle Novetsky Friedman (ORCID: https://orcid.org/0000-0003-4668-9176)
Saro H. Armenian (ORCID: https://orcid.org/0000-0003-2604-8603)
Smita Bhatia (ORCID: https://orcid.org/0000-0002-7755-5683)
David K. Crossman (ORCID: https://orcid.org/0000-0002-0981-169X)
Wendy Landier (ORCID: https://orcid.org/0000-0003-3319-5652)
Purnima Singh (ORCID: https://orcid.org/0000-0002-4968-7398)
Joseph P. Neglia (ORCID: https://orcid.org/0000-0002-5525-0598)
Melissa A. Richard (ORCID: https://orcid.org/0000-0003-0129-9860)
Douglas S. Hawkins (ORCID: https://orcid.org/0000-0003-3602-1375)
Melissa M. Hudson (ORCID: https://orcid.org/0000-0001-6984-2407)
Zhaoming Wang (ORCID: https://orcid.org/0000-0001-7556-3869)
Xuexia Wang (ORCID: https://orcid.org/0000-0002-0613-2608)

Institutions

Seattle Children's Hospital (US)
City Of Hope National Medical Center (US)
University of Minnesota (US)
St. Jude Children's Research Hospital (US)
Memorial Sloan Kettering Cancer Center (US)
Baylor College of Medicine (US)
Florida International University (US)
University of Alabama at Birmingham (US)
Masonic Cancer Center

Publication Details

Journal: Journal of Clinical Oncology
Published: 2025-08-19
DOI: https://doi.org/10.1200/jco-25-00542
Primary Topic: Childhood Cancer Survivors' Quality of Life
Type: article
Field-Weighted Citation Impact: 0.00

Germline Pathogenic/Likely Pathogenic Mutations and Subsequent Neoplasms Among Childhood Cancer Survivors: A Report From the Children's Oncology Group ALTE03N1 Study

Joshua Richman, Liting Zhou, M. A. Sheikh, Lindsey Hageman, Ravi Bhatia, Changde Cheng, Noha Sharafeldin, Patrick J. Trainor, Danielle Novetsky Friedman, Saro H. Armenian, Smita Bhatia, David K. Crossman, Wendy Landier, Purnima Singh, Joseph P. Neglia, Melissa A. Richard, Douglas S. Hawkins, Melissa M. Hudson, Zhaoming Wang, Xuexia Wang

August 19, 2025article en

Germline Pathogenic/Likely Pathogenic Mutations and Subsequent Neoplasms Among Childhood Cancer Survivors: A Report From the Children's Oncology Group ALTE03N1 Study

Authors

Institutions

Publication Details

Germline Pathogenic/Likely Pathogenic Mutations and Subsequent Neoplasms Among Childhood Cancer Survivors: A Report From the Children's Oncology Group ALTE03N1 Study

Germline Pathogenic/Likely Pathogenic Mutations and Subsequent Neoplasms Among Childhood Cancer Survivors: A Report From the Children's Oncology Group ALTE03N1 Study

Abstract

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