When huffing and puffing Ca2+ goes global, breast cancer cells are unmoved
In this issue, Militsin et al. (https://doi.org/10.1083/jcb.202411203) reveal how STIM1 and STIM2-beyond their typical role as ER Ca2+ sensors that activate Orai1-control IP3R-mediated Ca2+ dynamics, thereby regulating breast cancer cell migration and invasion.
Authors
- Shmuel Muallem (ORCID: https://orcid.org/0000-0002-6189-4947)
- Woo Young Chung
Institutions
- National Institute of Dental and Craniofacial Research (US)
Publication Details
- Journal
- The Journal of Cell Biology
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1083/jcb.202507062
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health