Fatal Lead Toxicity From Ayurvedic Supplements in a Patient With Parkinson’s Disease

Lead poisoning is rare in adults, particularly when the source of exposure is not immediately apparent. This case describes a 76-year-old woman with Parkinson's disease who presented with altered mental status after taking Ayurvedic supplements for several weeks. Clinical evaluation revealed a blood lead level greater than 90 µg/dL (measured after her supplement use was identified) and abdominal imaging that demonstrated radiopaque material throughout the colon, findings consistent with lead ingestion. Although chelation therapy was initiated promptly, her condition worsened due to progressive neurologic decline and the development of secondary infections. After discussions with her family, the focus of care was transitioned to comfort measures. This case highlights the importance of obtaining a thorough medication history, including over-the-counter and alternative therapies, both on admission and throughout hospitalization. It also underscores the serious risks associated with heavy metal exposure, particularly in patients with preexisting neurologic disorders, and the need for early, guideline-based management.