Cytotoxic CD8+ T Cells Downregulate GPX4 to Promote Ferroptosis in Melanoma That Drives Antitumor Immunity
CD8+ T cells directly interact with melanoma cells to downregulate the essential antioxidant enzyme GPX4 and stimulate ferroptosis, which is a crucial driver of immune cell-mediated melanoma clearance.
Authors
- Goran Micevic (ORCID: https://orcid.org/0000-0003-0329-1053)
- William Damsky (ORCID: https://orcid.org/0000-0003-0975-4071)
- Simon F. Roy (ORCID: https://orcid.org/0000-0002-5444-0349)
- Meaghan K. McGeary (ORCID: https://orcid.org/0000-0002-8505-7158)
- Andrew J. Daniels (ORCID: https://orcid.org/0000-0001-5146-310X)
- Karine Flem‐Karlsen (ORCID: https://orcid.org/0000-0001-8405-3406)
- Ronan Talty (ORCID: https://orcid.org/0000-0002-8742-3799)
- Durga Thakral (ORCID: https://orcid.org/0000-0001-5420-3354)
- Koonam Park (ORCID: https://orcid.org/0000-0001-5480-3915)
- Marcus Bosenberg (ORCID: https://orcid.org/0000-0003-0166-1612)
- Veronica T. Brooks (ORCID: https://orcid.org/0009-0006-0069-5967)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Yale Cancer Center (US)
- Yale University (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1158/0008-5472.can-24-1952
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05