Clinical significance of anti-mitochondrial antibodies and PBC-specific anti-nuclear antibodies in evaluating atypical primary biliary cholangitis with normal alkaline phosphatase levels
Over 50 % of patients with positive PBC-specific antibodies and normal ALP have PBC. Liver biopsy is recommended when AMAs and/or PBC-specific ANAs are positive, especially when baseline serum IgM exceeds 0.796 × ULN, and when other etiologies related to liver disease are absent. The area under the curve (AUC) for these three indicators reaches 0.84.
Authors
- Miaoyang Chen
- Yuan Yang
- Jialuo Wang
- Kai Zhang (ORCID: https://orcid.org/0000-0003-4426-1897)
- Shasha Li (ORCID: https://orcid.org/0000-0002-2498-6893)
- Xing Liu (ORCID: https://orcid.org/0000-0003-3655-5000)
- Hongli Liu (ORCID: https://orcid.org/0000-0003-3343-9645)
- Yongfeng Yang (ORCID: https://orcid.org/0000-0002-3214-0038)
- Yuxiang Gong
Institutions
- Nanjing University of Chinese Medicine (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Nanjing Second Hospital (CN)
- Southeast University (CN)
Publication Details
- Journal
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1515/cclm-2025-0357
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province