<i>TSC22D1</i> promotes liver sinusoidal endothelial cell dysfunction and induces macrophage M1 polarization in non-alcoholic fatty liver disease
Our findings indicate a pivotal role of <i>TSC22D1</i> in NAFLD fibrosis, demonstrating its dual function in regulating LSEC dysfunction and inflammatory responses. <i>TSC22D1</i> may be a promising target for the treatment and the prevention and management of NAFLD progression to fibrosis.
Authors
- Xinqi Xu (ORCID: https://orcid.org/0000-0003-2607-5230)
- Lili Wu (ORCID: https://orcid.org/0000-0002-1451-477X)
- Xuezhong Xu (ORCID: https://orcid.org/0000-0001-9232-3381)
- Yongmin Yan (ORCID: https://orcid.org/0000-0002-1990-1170)
- Huaji Jiang (ORCID: https://orcid.org/0000-0003-0197-239X)
- Qun Wang (ORCID: https://orcid.org/0000-0002-5946-2918)
- Jun Dong
- Yiqin Wang (ORCID: https://orcid.org/0000-0002-8424-6053)
- Wei Ding (ORCID: https://orcid.org/0000-0003-0482-5977)
- Yulin Tan (ORCID: https://orcid.org/0000-0002-9160-7611)
- Weiwei Chen (ORCID: https://orcid.org/0000-0001-8616-1419)
- Yibo Wang (ORCID: https://orcid.org/0009-0009-8934-9754)
Institutions
- Jiangsu University (CN)
- Xuzhou Medical College (CN)
- Changzhou No.2 People's Hospital (CN)
Publication Details
- Journal
- World Journal of Gastroenterology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.3748/wjg.v31.i31.109605
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71