Integration of multi-omics data reveals dysregulated RNA methylation in retinal pigment epithelium drives age-related macular degeneration
The results reveal the implication of dysregulation of RNA methylation-related gene expression in the RPE of AMD patients and further demonstrated a causal association between RNA methylation-related genes (<i>METTL3</i>, <i>NSUN6</i>, and <i>MRM1</i>) and AMD. These findings highlight the importance of RNA methylation in the pathogenesis of AMD and offer potential biomarkers and therapeutic targets for AMD management.
Authors
- Xiaoying Zhou (ORCID: https://orcid.org/0000-0003-3298-5089)
- Qiang Wang (ORCID: https://orcid.org/0000-0002-3849-1349)
- Yajun Gong
Institutions
- Central South University (CN)
- Sun Yat-sen University (CN)
- The First People's Hospital of Changde (CN)
Publication Details
- Journal
- International Journal of Ophthalmology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.18240/ijo.2025.09.03
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Natural Science Foundation of Guangdong Province
- Natural Science Foundation of Hunan Province
- Fundamental Research Funds for the Central Universities