High-grade glioma with pleomorphic and pseudopapillary features: a single-institution series of three cases
HPAP is a novel clinical entity demonstrating variable molecular signatures sharing a common DNA methylation profile which demonstrates a relatively favorable clinical course when compared with other high grade gliomas. Further study is needed to determine the optimal treatment and factors that influence survival.
Authors
- Subasree Srinivasan
- Rasha Alfattal (ORCID: https://orcid.org/0000-0001-6144-3233)
- Maria A. Gubbiotti (ORCID: https://orcid.org/0000-0003-2246-7958)
- Vinay K. Puduvalli (ORCID: https://orcid.org/0000-0001-8396-9500)
- Jeffrey S. Weinberg (ORCID: https://orcid.org/0000-0001-5587-6673)
- Sherise Desiree Ferguson (ORCID: https://orcid.org/0000-0002-6344-0615)
- Pushan Dasgupta (ORCID: https://orcid.org/0000-0002-7977-5591)
- Leomar Y. Ballester (ORCID: https://orcid.org/0000-0002-6854-6830)
- Eric A. Goethe (ORCID: https://orcid.org/0000-0002-4151-2059)
- Sujit S. Prabhu
- Shiao-Pei Weathers
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Baylor College of Medicine (US)
- The University of Texas Health Science Center (US)
Publication Details
- Journal
- Acta Neuropathologica Communications
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1186/s40478-025-02097-7
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- National Institutes of Health