Clinical experience of genome-wide non-invasive prenatal testing as a first-tier screening test in a cohort of 59,771 pregnancies
GW-NIPT has high sensitivity in screening fetal aneuploidy and moderate clinical utility in detecting CNV and fetal mosaicism, demonstrating that GW-NIPT holds significant application value in current and future prenatal screening procedures.
Authors
- Quanfu Zhang
- Jianxin Zhen (ORCID: https://orcid.org/0000-0003-4899-4422)
- Weihong Wang (ORCID: https://orcid.org/0000-0002-7022-3897)
- Xi Chen (ORCID: https://orcid.org/0000-0002-2058-0351)
- Xia Li (ORCID: https://orcid.org/0000-0002-9794-2648)
- Liting Zhang (ORCID: https://orcid.org/0000-0003-4919-2667)
- Huilin Wang (ORCID: https://orcid.org/0009-0002-2691-0419)
Institutions
- Shenzhen Bao'an District People's Hospital (CN)
- Shenzhen Children's Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1371/journal.pone.0329463
- Citations
- 4
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 13.98
Funders
- National Natural Science Foundation of China