Misleading detection of herpes simplex virus type 1 in a patient with paraneoplastic encephalitis
Onconeural antibodies, such as anti-Hu antibodies, are an under-recognized cause of encephalitis and should be specifically tested for when an autoimmune encephalitis is clinically suspected.Detection of anti-Hu antibodies mandates a comprehensive malignancy workup.A positive herpes simplex virus type 1 polymerase chain reaction in cerebrospinal fluid does not definitively confirm active infection and must always be interpreted in conjunction with the patient's clinical presentation.
Authors
- Marten Trendelenburg (ORCID: https://orcid.org/0000-0001-7036-8386)
- Mirko Lischer (ORCID: https://orcid.org/0000-0001-7088-2801)
- Gerardo A. Martí (ORCID: https://orcid.org/0000-0002-9442-2559)
- Özgür Yaldizli (ORCID: https://orcid.org/0000-0002-0800-4845)
- Nikolaos S. Avramiotis (ORCID: https://orcid.org/0000-0001-7365-672X)
- A. Vital (ORCID: https://orcid.org/0000-0001-7665-2898)
Institutions
- University Hospital of Basel (CH)
- Spital STS (CH)
Publication Details
- Journal
- European Journal of Case Reports in Internal Medicine
- Published
- 2025-08-18
- DOI
- https://doi.org/10.12890/2025_005705
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00