Altered functional connectivity of the hippocampus in cortico-subcortical networks in early-stage and emerging psychosis
Our findings show lower connectivity between the hippocampus and frontal cortex in early-stage psychosis, with FEP patients showing stronger decreases in connectivity compared to CHR-Ps. Furthermore, network-based analyses highlight reduced centrality in FEPs compared to CHR-Ps, indicating reduced influence on the wider network. Thus, altered connectivity along the hippocampal-frontal axis could be a potential marker of illness stage in early-stage psychosis.
Authors
- Joachim Groß (ORCID: https://orcid.org/0000-0002-3994-1006)
- Matthias Schwannauer (ORCID: https://orcid.org/0000-0002-4683-2596)
- Andrew Gumley (ORCID: https://orcid.org/0000-0002-8888-938X)
- Peter J. Uhlhaas (ORCID: https://orcid.org/0000-0002-0892-2224)
- Rajeev Krishnadas (ORCID: https://orcid.org/0000-0001-6845-5894)
- Frauke Schultze‐Lutter (ORCID: https://orcid.org/0000-0003-1956-9574)
- Ruchika Gajwani (ORCID: https://orcid.org/0000-0002-1199-320X)
- Gina Brunner
- Stephen M. Lawrie (ORCID: https://orcid.org/0000-0002-2444-5675)
- Alessio Fracasso (ORCID: https://orcid.org/0000-0002-4542-112X)
Institutions
- University of Bern (CH)
- Universitas Airlangga (ID)
- University of Münster (DE)
- Heinrich Heine University Düsseldorf (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Glasgow (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- European Archives of Psychiatry and Clinical Neuroscience
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1007/s00406-025-02079-9
- Citations
- 1
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Charité – Universitätsmedizin Berlin