The leader of the capsid protein from <i>Feline calicivirus</i> must be palmitoylated and form oligomers through disulfide bonds for efficient viral replication

Feline calicivirus (FCV) is a highly transmissible virus that represents a significant cause of upper respiratory infection in domestic and wild cats worldwide. FCV also serves as one of the most valuable models for studying calicivirus biology, as unlike most members of the family, known to cause diseases in animals and humans, it can be easily grown in cell culture. Since there are no efficacious vaccines or antivirals against most caliciviruses, understanding their molecular biology and the relationship between viral and cellular components is essential for developing strategies for their prevention and control.