Molecular stratification of prostate cancer through sensory perception-related multi-omics analysis reveals chemoresistant mechanisms
This study establishes sensory perception-associated molecular subtypes in PCa and links CS1 chemoresistance to immune microenvironment reprogramming via TNF-CCL20 signaling. These findings offer mechanistic insights into PCa progression and suggest actionable targets to overcome therapeutic resistance.
Authors
- Yu Sun (ORCID: https://orcid.org/0000-0001-7895-0741)
- Wei Wang (ORCID: https://orcid.org/0000-0003-0876-2205)
- Xu Tian (ORCID: https://orcid.org/0009-0003-8909-070X)
- Ye Tian (ORCID: https://orcid.org/0000-0003-1290-2223)
- Shi Li
Institutions
- Shanghai Jiao Tong University (CN)
- Dalian University of Technology (CN)
- Dalian Municipal Central Hospital (CN)
Publication Details
- Journal
- Cellular Oncology
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1007/s13402-025-01099-w
- Citations
- 1
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Dalian University of Technology