<i>Lactobacillus crispatus</i> -derived nCEV vesicles promote cutaneous wound healing and inhibit HPV16 infection
This study identifies <i>Lactobacillus crispatus</i>-derived vesicles (nCEVs) as crucial for cervicovaginal homeostasis, functioning through promoting wound healing via macrophage polarization and blocking HPV infection, and delivering D-lactate-a key bioactive component. These insights advance microbiome-based female healthcare interventions.
Authors
- Ke Peng (ORCID: https://orcid.org/0000-0002-6933-8160)
- Fang Wei (ORCID: https://orcid.org/0000-0001-8964-1645)
- Lina Liu (ORCID: https://orcid.org/0000-0002-5251-5116)
- Shujun Gao (ORCID: https://orcid.org/0000-0002-3217-7519)
- Qiliang Cai (ORCID: https://orcid.org/0000-0002-7147-0953)
- Shujuan Du
- Yuyan Wang (ORCID: https://orcid.org/0000-0003-1405-1821)
- Caixia Zhu
- Yulin Zhang (ORCID: https://orcid.org/0009-0000-7170-0475)
- Xiao-Ting Chen
- Qianwen Huang (ORCID: https://orcid.org/0000-0003-4493-4721)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Shanghai Jiao Tong University (CN)
- International Peace Maternity & Child Health Hospital (CN)
- Baoji City Central Hospital (CN)
- Center for Life Sciences (CN)
Publication Details
- Journal
- mSystems
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1128/msystems.00683-25
- Citations
- 5
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.77
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Program of Shanghai Academic Research Leader