KAT6A chimeras form a self-reinforcing epigenetic module with NURF and MLL/COMPASS to sustain AML
Our study identifies a self-reinforcing epigenetic module of histone modifiers and readers in KAT6A-rearranged AML, providing mechanistic insights into the genomic targeting of KAT6A chimeras and highlighting promising combinatorial therapeutic strategies.
Authors
- Zhinang Yin (ORCID: https://orcid.org/0000-0002-1275-3929)
- Zemin Song
- Ying Xiang (ORCID: https://orcid.org/0000-0001-9165-3346)
- Junhui Lv (ORCID: https://orcid.org/0000-0002-5661-0540)
- Rui Lu (ORCID: https://orcid.org/0000-0001-5943-862X)
- Kaiwei Liang (ORCID: https://orcid.org/0000-0002-6021-353X)
- R. Xiao (ORCID: https://orcid.org/0000-0002-5753-6557)
- Li‐Min Huang (ORCID: https://orcid.org/0000-0002-9291-260X)
- Hai‐Bing Zhou (ORCID: https://orcid.org/0000-0001-8498-063X)
- Jian Ni (ORCID: https://orcid.org/0000-0001-5411-7050)
- Pingping Fang (ORCID: https://orcid.org/0000-0001-5305-2830)
- Ying Zhou (ORCID: https://orcid.org/0000-0002-3614-2647)
- Honghong Wang (ORCID: https://orcid.org/0000-0002-3485-9046)
- Hongmei Wen (ORCID: https://orcid.org/0000-0002-0339-2498)
- Conghui Li (ORCID: https://orcid.org/0000-0002-4991-4474)
- Peiyuan Yang (ORCID: https://orcid.org/0009-0007-2662-6801)
Institutions
- Wuhan University (CN)
Publication Details
- Journal
- Genome biology
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1186/s13059-025-03743-y
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- Wuhan University
- National Science and Technology Major Project
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China