Clonorchis sinensis-driven hepatocarcinogenesis via E2F1-CD24 transcriptional axis: mechanistic and therapeutic implications
Our findings establish a novel parasitic carcinogenesis paradigm wherein C. sinensis promotes HCC development through E2F1-mediated transcriptional activation of CD24, simultaneously identifying prognostic biomarkers and therapeutic targets while suggesting combinatory immunotherapy strategies for parasite-associated HCC.
Authors
- Tao Peng (ORCID: https://orcid.org/0000-0002-5578-5314)
- Guangzhi Zhu (ORCID: https://orcid.org/0000-0001-5958-7289)
- Jing Zhou (ORCID: https://orcid.org/0000-0002-8420-5462)
- Guo‐Dong Lu (ORCID: https://orcid.org/0000-0001-6056-3196)
- Yong Wu (ORCID: https://orcid.org/0000-0002-1698-0897)
- Qian-Ru Cui
- Wen‐Min Lu (ORCID: https://orcid.org/0000-0003-2410-8502)
- Yu Chen (ORCID: https://orcid.org/0000-0003-4015-5181)
- Feng Ji
- Jin Yan (ORCID: https://orcid.org/0009-0008-4930-0502)
- Zhongfan Liu (ORCID: https://orcid.org/0000-0001-5554-1902)
Institutions
- Sun Yat-sen University (CN)
- Guangxi Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- National Cancer Center (US)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Guangxi Center for Disease Prevention and Control (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1186/s13071-025-06979-6
- Citations
- 1
- Primary Topic
- Parasites and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 2.05
Funders
- National Natural Science Foundation of China