Herb-Drug Interaction Between Sailuotong and Pitavastatin: A Systematic Pharmacokinetic Investigation and Mechanism Analysis
Combining SLT and PIV can lead to HDIs, with multiple doses of SLT significantly reducing the plasma and hepatic exposure of PIV in rats. The primary mechanism appears to be the induction of the intestinal efflux transporter MDR1, resulting in decreased bioavailability of PIV.
Authors
- Chang-Ying Ren
- Yuchen Song (ORCID: https://orcid.org/0000-0002-0940-3178)
- Huan Yi
- Ying Zhang (ORCID: https://orcid.org/0000-0001-7520-3193)
- Li Xiang (ORCID: https://orcid.org/0000-0002-7569-6677)
- Hongtian Yang (ORCID: https://orcid.org/0000-0001-7858-0939)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China Academy of Chinese Medical Sciences (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-08-01
- DOI
- https://doi.org/10.2147/dddt.s529385
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Academy of Chinese Medical Sciences