Metabolomics and nutrient intake reveal metabolite–nutrient interactions in metabolic syndrome: insights from the Korean Genome and Epidemiology Study

This comprehensive metabolomic analysis of the KoGES Ansan-Ansung cohort revealed distinct metabolic profiles and nutrient intake patterns associated with MetS, highlighting altered metabolite-nutrient relationships and disrupted metabolic pathways. These findings provide new insights into potential associations between metabolic phenotypes and dietary intake, which may help inform individualized dietary approaches related to MetS, such as branched-chain amino acids-restricted diets (valine, isoleucine, leucine), reduced intake of hexose-rich carbohydrates, and modulation of niacin-rich protein sources according to individual metabolic profiles.