Divergent Clonal Evolution and Early Dissemination Promote Genetic Heterogeneity of Metastases in Castration-Resistant Prostate Cancer
Genomic analysis of a multisite metastatic prostate cancer cohort reveals patterns of clonal heterogeneity, dissemination, and evolution, highlighting the need to evaluate multiple samples to fully characterize the clonal architecture of tumors. This article is part of a special series: Driving Cancer Discoveries with Computational Research, Data Science, and Machine Learning/AI .
Authors
- Arul M. Chinnaiyan (ORCID: https://orcid.org/0000-0001-9282-3415)
- Noshad Hosseini (ORCID: https://orcid.org/0000-0003-3761-0198)
- Xuhong Cao (ORCID: https://orcid.org/0000-0002-2455-3086)
- Ryan J. Rebernick (ORCID: https://orcid.org/0000-0002-5532-581X)
- Ana Lako (ORCID: https://orcid.org/0000-0003-2931-6212)
- Marcin Cieślik (ORCID: https://orcid.org/0000-0002-5467-1040)
- Joshi J. Alumkal (ORCID: https://orcid.org/0000-0003-1278-0166)
- Rahul Mannan (ORCID: https://orcid.org/0000-0002-6642-0468)
- Rohit Mehra (ORCID: https://orcid.org/0000-0002-6955-8884)
- Fengyun Su (ORCID: https://orcid.org/0000-0003-4868-6745)
- Dattatreya Mellacheruvu (ORCID: https://orcid.org/0000-0001-8221-7673)
- Zachery R. Reichert (ORCID: https://orcid.org/0000-0003-0356-8796)
- Rui Wang (ORCID: https://orcid.org/0000-0002-5356-9685)
- Jing Hu (ORCID: https://orcid.org/0000-0001-7604-6732)
- Rohit Malik (ORCID: https://orcid.org/0009-0000-5862-9731)
Institutions
- Howard Hughes Medical Institute (US)
- University of Michigan (US)
- Michigan Medicine (US)
- Michigan Center for Translational Pathology (US)
- Bristol-Myers Squibb (Belgium) (BE)
- Ann Arbor Center for Independent Living (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3687
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00