Two-step Mendelian randomization reveals a lipid-driven protective effect of type 2 diabetes on ALS
T2DM's protective influence on ALS primarily involves lipid rather than glucose pathways, highlighting TEC and LDL particle diameter as crucial mediators. Targeting lipid metabolism may offer new therapeutic strategies to reduce ALS risk or progression, potentially leading to focused nutritional interventions and biomarker development.
Authors
- Mingjun Kong
- Dongsheng Fan (ORCID: https://orcid.org/0000-0002-3129-9821)
- Wei Yu (ORCID: https://orcid.org/0000-0002-1174-596X)
- Jianhui Guo (ORCID: https://orcid.org/0000-0001-5731-9328)
- Zhuoya Wang (ORCID: https://orcid.org/0009-0003-1920-0061)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Peking University (CN)
- National Health and Family Planning Commission (CN)
- Biomarker Technologies (China) (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Peking University Third Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Neurological Sciences
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1007/s10072-025-08407-0
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China