Comparative Transcriptomic and Metabolomic Analyses Reveal the Mechanism by Which Foam Macrophages Restrict Survival of Intracellular <i>Mycobacterium Tuberculosis</i>.
FMs inhibit MTB survival. The cAMP signaling pathway is a key contributor. These findings enhance the understanding of the role of FMs in tuberculosis progression, suggest potential targets for host-directed therapies, and offer new directions for developing diagnostic and therapeutic strategies against tuberculosis.
Authors
- Li Yao Chen
- Yong Guo (ORCID: https://orcid.org/0000-0003-1746-5544)
- Ye Yang (ORCID: https://orcid.org/0000-0002-2101-0609)
- Jie Lu (ORCID: https://orcid.org/0009-0000-3143-1872)
- Xuan Zhang (ORCID: https://orcid.org/0000-0001-8775-1699)
- Xiao Peng (ORCID: https://orcid.org/0000-0001-8116-1372)
- Yuan Yuan Liu
- Anqi Jia (ORCID: https://orcid.org/0009-0003-1321-6441)
- Hui Yang (ORCID: https://orcid.org/0000-0002-4570-0356)
- Yan Chang
- Ying Yu
Institutions
- Beijing Children’s Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-07-20
- DOI
- https://doi.org/10.3967/bes2025.078
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00