Stability of alglucosidase alfa in 0.9% sodium chloride for enzyme replacement therapy in patients with Pompe disease: insights from enzyme activity and cellular uptake measurements
Ready-to-administer alglucosidase alfa infusion in 0.9% sodium chloride at 2-4 mg/mL is stable for 11 days when stored at 2-8°C or -20°C and protected from light. Extending the stability could enhance efficiency and flexibility for infusion preparation and home delivery, while minimising pharmaceutical waste.
Authors
- Tim Preijers (ORCID: https://orcid.org/0000-0001-6953-0358)
- Edwin H. Jacobs
- Jan-Dietert C. Brugma
- P.H.M. van der Kuy (ORCID: https://orcid.org/0000-0002-7128-8801)
- Ina Barzel (ORCID: https://orcid.org/0000-0003-4251-8011)
- Marianne Hoogeveen‐Westerveld
Institutions
- Erasmus MC (NL)
Publication Details
- Journal
- European Journal of Hospital Pharmacy
- Published
- 2025-08-17
- DOI
- https://doi.org/10.1136/ejhpharm-2025-004516
- Citations
- 2
- Primary Topic
- Lysosomal Storage Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 2.33