Association between Ki-67 and clinical outcomes in 324 Chinese patients with resectable acral melanoma

The relationship between Ki-67 expression and clinical prognosis in patients with resectable acral melanoma (AM) remains unclear. This study explores the prognostic role of Ki-67 in AM using data from 324 patients across five Chinese centers. Patients were divided into low Ki-67 expression and high Ki-67 expression groups based on pathological reports. The log-rank test was used to compare disease-free survival (DFS) and overall survival (OS), and the Cox proportional hazards regression model was employed to identify prognostic factors. Among the 324 patients included in the study, 181 (55.8%) were in the low Ki-67 expression group, and 143 (44.2%) were in the high Ki-67 expression group. The high Ki-67 expression group exhibited a higher incidence of tumor thickness > 4 mm (45.5% vs 24.3%, P < 0.001), ulceration (65.7% vs 54.1%, P = 0.035), stage III (31.5% vs 16.0%, P < 0.001), LDH ≥ 250 U/L (14.0% vs. 6.6%, P = 0.028), and positive sentinel lymph nodes (28.0% vs 11.1%, P = 0.029). High Ki-67 predicted shorter DFS (26.8 vs 74.1 months, P = 0.025) and OS (52.1 months vs NR, P < 0.001). Multivariate analysis identified Ki-67, age, stage and LDH as independent OS predictors.

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Publication Details

Journal
Scientific Reports
Published
2025-08-17
DOI
https://doi.org/10.1038/s41598-025-15751-w
Citations
1
Primary Topic
Cutaneous lymphoproliferative disorders research
Type
article
Field-Weighted Citation Impact
2.00
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article

Association between Ki-67 and clinical outcomes in 324 Chinese patients with resectable acral melanoma

Weizhen Zhang, Hongxue Meng, Di Wu, Jianping Gui et al.
1 citations
Scientific Reports
Cutaneous lymphoproliferative disorders research
2.00
article

Association between Ki-67 and clinical outcomes in 324 Chinese patients with resectable acral melanoma

Weizhen Zhang, Hongxue Meng, Di Wu, Jianping Gui, Jiwei Liu, Yan Wang, Mei Xiang, Hongfeng Zhou, Yi Teng, Fang Liu, Xin Cai, Jin Wu, Zhen Guo, Kui Jiang, Xiang Ji
article en
1 citations

Abstract

The relationship between Ki-67 expression and clinical prognosis in patients with resectable acral melanoma (AM) remains unclear. This study explores the prognostic role of Ki-67 in AM using data from 324 patients across five Chinese centers. Patients were divided into low Ki-67 expression and high Ki-67 expression groups based on pathological reports. The log-rank test was used to compare disease-free survival (DFS) and overall survival (OS), and the Cox proportional hazards regression model was employed to identify prognostic factors. Among the 324 patients included in the study, 181 (55.8%) were in the low Ki-67 expression group, and 143 (44.2%) were in the high Ki-67 expression group. The high Ki-67 expression group exhibited a higher incidence of tumor thickness > 4 mm (45.5% vs 24.3%, P < 0.001), ulceration (65.7% vs 54.1%, P = 0.035), stage III (31.5% vs 16.0%, P < 0.001), LDH ≥ 250 U/L (14.0% vs. 6.6%, P = 0.028), and positive sentinel lymph nodes (28.0% vs 11.1%, P = 0.029). High Ki-67 predicted shorter DFS (26.8 vs 74.1 months, P = 0.025) and OS (52.1 months vs NR, P < 0.001). Multivariate analysis identified Ki-67, age, stage and LDH as independent OS predictors.

Scientific ReportsVol. 15(1)
Harbin Medical University (CN), Dalian Medical University (CN), Jilin University (CN), Second Affiliated Hospital of Dalian Medical University (CN), Third Affiliated Hospital of Harbin Medical University (CN), First Hospital of Jilin University (CN), Changchun University of Chinese Medicine (CN), First Affiliated Hospital of Dalian Medical University (CN), Third Affiliated Hospital of Zhengzhou University (CN), Zhengzhou People's Hospital (CN)
Good health and well-being
Openalex Percentile: Top 12%
Cutaneous lymphoproliferative disorders research
2.00
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