Impaired humoral and T helper cell responses to toxic shock syndrome toxin-1 (TSST-1) in granulomatosis with polyangiitis
Impaired humoral immunity against Vβ2-restricted superantigens in SA+ GPA patients may lead to insufficient clearance of TSST-1. TSST-1-driven IL-21 production could enhance ANCA production and promote disease progression. Reduced Vβ2+Th cells may increase relapse risk, emphasizing their potential value as a tool for monitoring disease progression.
Authors
- Wayel H. Abdulahad (ORCID: https://orcid.org/0000-0003-3109-4487)
- Minke G. Huitema
- Peter Heeringa (ORCID: https://orcid.org/0000-0001-8684-763X)
- Abraham Rutgers (ORCID: https://orcid.org/0000-0002-1641-6890)
- Caroline Roozendaal (ORCID: https://orcid.org/0000-0001-7111-0379)
- Hang Liao (ORCID: https://orcid.org/0000-0002-3475-2177)
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1093/rheumatology/keaf439
- Primary Topic
- Peripheral Neuropathies and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00