ISG15 deficiency in hepatic stellate cells promotes TGFβ2-induced liver fibrosis by counteracting CREB1 ISGylation
ISG15 regulated HSC activation and liver fibrosis in part via the CREB1/TGFβ2/SMAD2 regulatory pathway. Utilisation of ISG15-CREB1 signalling may be a potential therapeutic target for liver fibrosis.
Authors
- Dean Rao (ORCID: https://orcid.org/0000-0002-1134-6934)
- Yue Yuan (ORCID: https://orcid.org/0000-0002-2755-3751)
- Jianping Zhao (ORCID: https://orcid.org/0000-0003-3057-5617)
- Xin Long (ORCID: https://orcid.org/0000-0002-9817-5858)
- Bixiang Zhang (ORCID: https://orcid.org/0000-0002-1609-7260)
- Jiaxuan Li (ORCID: https://orcid.org/0000-0002-6146-9780)
- Min Chen (ORCID: https://orcid.org/0000-0002-2334-8320)
- Xiaoping Chen (ORCID: https://orcid.org/0009-0002-3306-2913)
- Qian Chen (ORCID: https://orcid.org/0009-0008-8951-5241)
- Huifang Liang (ORCID: https://orcid.org/0000-0001-6874-3634)
- Xun Lu (ORCID: https://orcid.org/0000-0002-4992-0241)
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Gut
- Published
- 2025-08-17
- DOI
- https://doi.org/10.1136/gutjnl-2025-335327
- Citations
- 2
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.64
Funders
- National Natural Science Foundation of China