Novel di-aryl chalcone derived pyrazole linked to methane sulfonyl pharmacophore as potent selective COX-2 inhibitors; design, synthesis, molecular modeling, <i>in vitro</i> and <i>in vivo</i> anti-inflammatory activities
The present work paves the way for further development of potent selective COX-2 inhibitors with anti-inflammatory activity.
Authors
- Mamdouh F. A. Mohamed (ORCID: https://orcid.org/0000-0002-7046-1799)
- Haredy Hassan Haredy
- Wael A. A. Fadaly
- Mohamed T. M. Nemr (ORCID: https://orcid.org/0000-0002-6650-6587)
- Ahmed H. Lotfallah (ORCID: https://orcid.org/0000-0002-8423-0692)
- Ahmed M. Sayed (ORCID: https://orcid.org/0000-0003-0244-3457)
- Abeer M. Abd El-Hameed (ORCID: https://orcid.org/0000-0002-9590-8534)
- Deiaa E Elsayed Abouzed (ORCID: https://orcid.org/0000-0002-1902-3814)
- Hoda Khalifa Abd-Elhady
Institutions
- Beni-Suef University (EG)
- Cairo University (EG)
- Nile Valley University (SD)
- Al-Azhar University (EG)
- South Valley University (EG)
- Taibah University (SA)
- Al-Azhar University (ID)
- École Nationale Supérieure d'Informatique (DZ)
- New Valley University
- Najran University (SA)
- University of El Salvador (SV)
- Sohag University (EG)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2025-08-03
- DOI
- https://doi.org/10.1080/17568919.2025.2545171
- Citations
- 9
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 8.42