Enhancing radiosensitivity of boron neutron capture therapy for liver cancer with homologous recombination repair inhibitor
Combining a RAD51 inhibitor with BA-BNCT significantly enhances the anti-tumor efficacy against radioresistant HCC and parental HCC cells. This proof-of-concept study suggests that the combination treatment can achieve comparable or superior therapeutic effects using lower radiation doses, thereby reinforcing the potential of BNCT for treating recurrent HCC.
Authors
- Yi‐Wei Chen (ORCID: https://orcid.org/0000-0003-3946-7540)
- Tianlun Zhou (ORCID: https://orcid.org/0000-0001-5864-0578)
- Jen‐Kun Chen (ORCID: https://orcid.org/0000-0002-3433-5971)
- Chi-Ying Lee (ORCID: https://orcid.org/0000-0001-5855-504X)
- Yung‐Jen Chuang (ORCID: https://orcid.org/0000-0002-6022-0107)
- Zih‐Yin Lai (ORCID: https://orcid.org/0000-0002-2694-9834)
- Yu‐Hsuan Huang (ORCID: https://orcid.org/0000-0001-5711-5624)
- Fong‐In Chou
- Y.M. Shiao
Institutions
- National Health Research Institutes (TW)
- National Tsing Hua University (TW)
- Taipei Veterans General Hospital (TW)
- TaiGen Biotechnology (Taiwan) (TW)
Publication Details
- Journal
- Japanese Journal of Radiology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1007/s11604-025-01852-z
- Citations
- 1
- Primary Topic
- Boron Compounds in Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- Ministry of Science and Technology
- National Tsing Hua University