Aquaporin-4 downregulation in dysphagic patients with idiopathic inflammatory myopathies: myofiber vulnerability and inflammation drivers
Myofiber hypotrophy appears to be due to inflammation from CD68-positive and MMP2-positive cells, whose activity disrupts the extracellular matrix and may detach AQP4 from the sarcolemma.
Authors
- Mariella Errede (ORCID: https://orcid.org/0000-0002-8163-2338)
- Francesco Girolamo (ORCID: https://orcid.org/0000-0001-8706-3386)
- Daniela Virgintino (ORCID: https://orcid.org/0000-0003-1041-5341)
- Florenzo Iannone (ORCID: https://orcid.org/0000-0003-0474-5344)
- Marco Fornaro (ORCID: https://orcid.org/0000-0003-1716-7432)
- Maria Luisa Fiorella (ORCID: https://orcid.org/0000-0001-9199-4132)
- Margherita Giannini (ORCID: https://orcid.org/0000-0002-4834-5804)
- Dario D’Abbicco
- Onofrio Valente (ORCID: https://orcid.org/0000-0002-6894-4644)
- Antonio Frigeri (ORCID: https://orcid.org/0000-0002-5284-2934)
Institutions
- Regenerative Medicine Institute (MX)
- Hôpital Civil, Strasbourg (FR)
- Mitochondrie, stress oxydant et protection musculaire (FR)
- University of Bari Aldo Moro (IT)
- Université de Strasbourg (FR)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-08-16
- DOI
- https://doi.org/10.1093/rheumatology/keaf436
- Primary Topic
- Eosinophilic Esophagitis
- Type
- article
- Field-Weighted Citation Impact
- 0.00