High Effectiveness of Ceftriaxone Monotherapy and Limited Value of Routine Test-of-Cure for Gonorrhea in a Low-Resistance Setting
We read with great interest the correspondence by , which confirms the effectiveness of ceftriaxone 1 g monotherapy for treating Neisseria gonorrhoeae (NG) compared to combination therapy with azithromycin, with also a minor impact on microbiome and resistance development.NG remains a priority pathogen due to rising incidence and the threat of antimicrobial resistance; however, resistance to ceftriaxone remains limited globally.In Europe, only isolated cases of reduced susceptibility have been reported, particularly in the United Kingdom, primarily linked to travel to the Asia-Pacific region [2].Based on these findings, we conducted a study (January 2022-March 2025) in Milan (Italy) to evaluate the effectiveness of 1 g ceftriaxone monotherapy versus combination regimens and to assess the utility of a test-of-cure (TOC) in a low-prevalence ----
Authors
- Davide Moschese (ORCID: https://orcid.org/0000-0001-5901-6742)
- Francesco Petri (ORCID: https://orcid.org/0000-0003-0125-9551)
- Federica Salari
- Davide Mileto (ORCID: https://orcid.org/0000-0002-9414-0287)
- Andrea Gori (ORCID: https://orcid.org/0000-0001-6587-4794)
- Alberto Rizzo
- Agostino Riva (ORCID: https://orcid.org/0000-0003-3171-3049)
- Francesco Caruso (ORCID: https://orcid.org/0000-0002-9665-9234)
- Maria Vittoria Cossu (ORCID: https://orcid.org/0000-0002-6984-3028)
- Cristina Gervasoni (ORCID: https://orcid.org/0000-0002-4922-6495)
- Chiara Fusetti (ORCID: https://orcid.org/0000-0002-1028-505X)
- Loriana Morelli
- Andrea Cavallo
- Alessandra Lombardi
Institutions
- University of Milan (IT)
- ASST Fatebenefratelli Sacco (IT)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1093/cid/ciaf456
- Citations
- 1
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 1.18