Biomineralized engineered <i>Lactococcus lactis</i>-based in situ vaccination enhances antitumor immunity via sequential activation of chemo-immunotherapy
We achieved the sequential activation of synergistic chemo-immunotherapy using an all-in-one biomineralized strategy. This study marked the first instance of biomineralizing probiotics with Mg-MOFs, creating a biosafe and versatile platform for combined in situ vaccination treatment.
Authors
- Junmeng Zhu
- Wei Rao
- Baorui Liu (ORCID: https://orcid.org/0000-0002-2539-7732)
- Xiaoping Qian (ORCID: https://orcid.org/0000-0002-5025-5269)
- Rutian Li (ORCID: https://orcid.org/0000-0003-4800-6156)
- Shaodong Hong (ORCID: https://orcid.org/0000-0002-5632-6857)
- Lanqi Cen
- Yan Wang (ORCID: https://orcid.org/0000-0001-9786-7492)
- Qin Liu (ORCID: https://orcid.org/0000-0001-9839-8480)
- Ziqi Chen (ORCID: https://orcid.org/0009-0007-4778-8826)
- Jie Shao (ORCID: https://orcid.org/0000-0003-1222-0505)
- Yanhong Chu
- Yaohua Ke
Institutions
- Nanjing University of Chinese Medicine (CN)
- China Pharmaceutical University (CN)
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1136/jitc-2025-011799
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.00