Kynu inhibition mitigates bile duct ischemic injury by rewiring tryptophan metabolism to restore tight junction integrity
Our findings demonstrated that Kynu inhibition alleviates bile duct ischemic injury by reprogramming dysregulated tryptophan metabolism, particularly through XA upregulation. This modulation may restore tight junction function via the GluR2/3/CX50-ZO1 axis, thereby preserving blood-biliary barrier integrity. Targeting Kynu represents a promising therapeutic strategy for ischemia-induced bile duct injury.
Authors
- Zhengchen Ye
- Bin Yang (ORCID: https://orcid.org/0000-0002-9778-8783)
- Ding Luo (ORCID: https://orcid.org/0009-0009-3428-819X)
- Guo-qing Bao
- Siliang Zhang (ORCID: https://orcid.org/0009-0007-7857-8004)
- Pinduan Bi
Institutions
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1186/s10020-025-01310-6
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China