Tumor-Specific EphA2 Receptor Tyrosine Kinase Inhibits Anti-Tumor Immunity by Recruiting Suppressive Myeloid Populations in Murine Models of Non-Small Cell Lung Cancer
Our studies suggest EphA2 on tumor cells recruits monocytes and promotes their differentiation into TAMs that likely inhibit the activation and infiltration of cytotoxic lymphocytes, promoting tumor immune escape.
Authors
- Dana M. Brantley‐Sieders (ORCID: https://orcid.org/0000-0002-2751-6547)
- Eileen Shiuan (ORCID: https://orcid.org/0000-0002-3202-4010)
- Shan Wang (ORCID: https://orcid.org/0000-0001-8292-5717)
Institutions
- University of California, Los Angeles (US)
- Vanderbilt University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Cancers
- Published
- 2025-08-19
- DOI
- https://doi.org/10.3390/cancers17162693
- Primary Topic
- Axon Guidance and Neuronal Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vanderbilt University
- National Institutes of Health