Case Report: Rapid resolution of fever after initiation of third-line rescue treatment with upadacitinib for acute severe ulcerative colitis in two young men

Upadacitinib seems to be a valuable option even as a second salvage therapy in ASUC. Randomized controlled trials are warranted. However, it has to be kept in mind that ASUC, especially with septic symptoms such as fever, remains a life-threatening condition in which surgery always has to be evaluated, and that multiple overlapping immunosuppressive therapies may cause severe complications, such as infections.