consHLA: a next generation sequencing consensus-based HLA typing workflow
To leverage cancer patient germline and tumour WGS and tumour RNA-seq data we developed an automated workflow, consHLA, that produces consensus typing of HLA genes in a clinically relevant timeframe. This workflow provides higher resolution patient HLA-typing than current gold standard approaches, identifies HLA alterations arising in patient tumours and generates clear, simple reports.
Authors
- Rachel Bowen-James (ORCID: https://orcid.org/0000-0002-9062-3644)
- Marie Wong-Erasmus
- Chelsea Mayoh (ORCID: https://orcid.org/0000-0002-6398-3046)
- Julian M.W. Quinn (ORCID: https://orcid.org/0000-0001-9674-9646)
- Mark J. Cowley (ORCID: https://orcid.org/0000-0002-9519-5714)
- Weilin Wu (ORCID: https://orcid.org/0000-0002-7517-1686)
Institutions
- UNSW Sydney (AU)
Publication Details
- Journal
- BMC Bioinformatics
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1186/s12859-025-06223-z
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Australia
- NSW Ministry of Health