Elevated serum levels of monocyte chemoattractant protein-1 in 71 patients 3 months after elective cardiac surgery suggest a potential link to persistent inflammation but not an increased propensity for perioperative cerebrovascular events
Serum MCP-1 levels were elevated for up to 3 months following cardiac surgery, even in patients who experienced an uneventful recovery. MCP-4 was unchanged, while RANTES depressed post-surgery. A significant correlation between MCP-1 and serum surrogate markers of brain injury, vascular inflammation, and atherosclerosis highlights MCP-1 as a potential biomarker and a possible mediator of adverse outcomes after cardiac surgery.
Authors
- Daniel A. Diedrich (ORCID: https://orcid.org/0000-0003-3688-3581)
- Mohamed A. Antar (ORCID: https://orcid.org/0000-0003-1000-3662)
- H. Gad (ORCID: https://orcid.org/0000-0001-5114-7844)
- Krzysztof Laudański (ORCID: https://orcid.org/0000-0002-7373-0851)
Institutions
- Mayo Clinic (US)
- WinnMed (US)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-08-18
- DOI
- https://doi.org/10.3389/fmed.2025.1561886
- Primary Topic
- Cardiac and Coronary Surgery Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of General Medical Sciences