Activation of mitophagy and proteasomal degradation confers resistance to developmental defects in postnatal skeletal muscle
These results highlight the role of mitophagy in postnatal skeletal muscle development and suggest that autophagy-deficiency triggers compensatory degradative pathways (i.e., UPS) to prevent mitochondrial apoptotic signaling and thus preserve skeletal muscle integrity in developing mice.
Authors
- Joe Quadrilatero (ORCID: https://orcid.org/0000-0002-9304-3557)
- Fasih A. Rahman (ORCID: https://orcid.org/0000-0003-4588-5378)
- Michelle M. Graham (ORCID: https://orcid.org/0000-0003-0708-7957)
- Amanda Truong (ORCID: https://orcid.org/0000-0001-9260-5418)
Institutions
- University of Waterloo (CA)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1186/s12929-025-01153-7
- Citations
- 2
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Natural Sciences and Engineering Research Council of Canada