Antiferroptotic Drugs Reduce sFlt-1 Release and Placenta Damage in Preeclampsia
This study establishes placental ferroptosis as a key mechanism in early preeclampsia and demonstrates its direct link to sFlt-1 dysregulation. Our systematic drug screening approach identified approved drugs with antiferroptotic activity, suggesting a novel therapeutic strategy for preeclampsia management through drug repurposing. Further research is needed to establish optimal dosing and confirm efficacy in vivo.
Authors
- Svetlana N. Samovich (ORCID: https://orcid.org/0000-0001-5731-122X)
- A.N. Plotnikov
- Sapir Lianski (ORCID: https://orcid.org/0000-0002-2906-2737)
- Debra Goldman‐Wohl (ORCID: https://orcid.org/0000-0002-5157-1917)
- S. Ananth Karumanchi (ORCID: https://orcid.org/0000-0002-2281-6831)
- Lilah Tsaitlin-Mor (ORCID: https://orcid.org/0000-0001-6603-4404)
- Ofer Beharier (ORCID: https://orcid.org/0000-0001-5317-4512)
- Vladimir A. Tyurin (ORCID: https://orcid.org/0000-0002-3474-1697)
- Alexandr A. Kapralov (ORCID: https://orcid.org/0000-0002-3006-916X)
- Tehila Mizrachi
- Haim Michael Barr (ORCID: https://orcid.org/0000-0001-9192-3983)
- Valerian E. Kagan (ORCID: https://orcid.org/0000-0002-7245-1885)
- Yulia Y. Tyurina (ORCID: https://orcid.org/0000-0003-0287-2091)
- Hülya Bayır (ORCID: https://orcid.org/0000-0003-2361-4120)
- Yoel Sadovsky (ORCID: https://orcid.org/0000-0003-2969-6737)
- Jacob Rachmilewitz (ORCID: https://orcid.org/0000-0002-6662-7987)
- R Medina (ORCID: https://orcid.org/0000-0001-8689-2932)
- S. M. Cohen (ORCID: https://orcid.org/0000-0001-6359-3729)
- Oren Barak (ORCID: https://orcid.org/0000-0002-7508-825X)
- S. Yagel
- Shirin Elhaik-Goldman
Institutions
- Cedars-Sinai Medical Center (US)
- Hebrew University of Jerusalem (IL)
- Hadassah Medical Center (IL)
- Kaplan Medical Center (IL)
- Magee-Womens Research Institute (US)
- Weizmann Institute of Science (IL)
- Oklahoma State University Center for Health Sciences (US)
- Columbia University (US)
Publication Details
- Journal
- Hypertension
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1161/hypertensionaha.125.25003
- Citations
- 6
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 12.34