Mechanical response microRNA-145a-5p alleviates osteoarthritis by inhibiting inflammation and promoting chondrogenesis
MiR-145a-5p, a mechanical responder, alleviates osteoarthritis progression through promoting chondrogenesis and alleviating inflammation response. And intra-articular injection of miR-145a-5p alleviates osteoarthritis progression. These findings suggest that miR-145a-5p is a promising target for the treatment of osteoarthritis.
Authors
- Ting Zhu
- Dong Jiang (ORCID: https://orcid.org/0000-0003-4380-7683)
- Danyang Bai (ORCID: https://orcid.org/0009-0003-6585-3688)
- Zhen Zhang (ORCID: https://orcid.org/0000-0001-9446-1139)
- Jingke Du
Institutions
- Peking University (CN)
- Shanghai Changzheng Hospital (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2025-08-19
- DOI
- https://doi.org/10.7717/peerj.19905
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China