Human Antibodies to M-Protein Epitope-Based Vaccines Demonstrate Increased Immunogenicity and Streptococcus pyogenes (StrepA) Bactericidal Activity
The high antigenic diversity of Streptococcus pyogenes (StrepA) presents extensive challenges to vaccine development; however, cryptic epitopes—conserved across emm types—offer an alternative approach [...]
Authors
- Simone Reynolds
- Christie Short
- Michael F. Good (ORCID: https://orcid.org/0000-0001-8212-248X)
- Michael Hawkes (ORCID: https://orcid.org/0000-0002-4122-0937)
- Gregory J. Tyrrell (ORCID: https://orcid.org/0000-0002-5276-2416)
- Avnish Kumar Seth (ORCID: https://orcid.org/0000-0003-0792-6984)
- Manisha Pandey (ORCID: https://orcid.org/0000-0002-4151-699X)
- Vanessa Meier‐Stephenson (ORCID: https://orcid.org/0000-0003-4004-4940)
- Victoria Ozberk (ORCID: https://orcid.org/0009-0008-1132-5413)
- D. Lorne Tyrrell (ORCID: https://orcid.org/0000-0002-0983-7267)
- Ijeoma Ogbuehi
- Michael Houghton (ORCID: https://orcid.org/0000-0003-3762-6771)
- Kelly Kim (ORCID: https://orcid.org/0000-0002-8475-9633)
Institutions
- Griffith University (AU)
- University of Alberta (CA)
Publication Details
- Published
- 2025-08-18
- DOI
- https://doi.org/10.3390/proceedings2025124018
- Primary Topic
- Streptococcal Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00